How Psychedelics will improve the world
neuron → mind → person → relationship → society → policy → future.
Quality of evidence. Explain randomized trials vs observational studies vs surveys vs mechanistic hypotheses.
Integration and lasting change. Explain why acute effects and long-term benefits are different.
Part III — From psychological change to everyday life
7. Presence, emotional regulation, and attention
Presence, attention, and reduced automaticity
8. Memory, reappraisal, and emotional processing
9. Relationships and connection
helping neurons helps system
Psychedelics have a significant potential to help people.
Psychedelics can help us understand others perspective which may increase unity
Presence makes 20% more happy
Presence dissolves negative emotions like anger and sadness. This makes you more happy yay
Why is there good and bad? most or all bad actions are caused by not managing negative emotions.
If everyone takes mushrooms periodically, then that makes the world more good.
Mushrooms give temporary presence by helping override attachments. Meditation and mushrooms are complimentary. They both make presnece. Mushrooms help give a window to presence.
Psychedelic Therapy
Psychedelics heal breakups
Inner Peace makes relational peace
World Peace is more easy to make with mushroom legalization. Because it makes you more happy inside.
Emotions are contagious and so if you are happy, then when you talk to others it makes other people happy. This increases connection, empathy and social cohesion. A minor incremental improvement in wellbeing ripples outward and then everyone gets a rainbow brain.
Psychedelics improve relationships
Unified Mind = more happy
Making others happy creates a positive upward spiral
New path to improve choice
The field of possibilities
Here we see a landscape of thought loops. Carhart-Harris and Friston’s 2019 REBUS paper proposes that psychedelics may relax the influence of strongly weighted high-level expectations. The old path is still here. It need not be the only path.
untie knots
see differently
Psychedelics help make everyone more happy
Psychedelics help with things like reinterpreting the past. This can make more happy and makes life more meaningful.
Memory
Psychedelics improve alignment
The closer you get to the moment the more wisdom you bring into it
Shared thinking improves cooperation
This increases networked consciousness between beings. This helps catalyze and accelerate knowledge transfer. This causes the stock market to boom. Which makes a Golden Age that never ends. Dune. The remade movies state that spice is a psychedelic. Spice is known to help with predicting the future, which is an inherent ability of the human mind. Psychedelics improve mental clarity
Default Mode Network
Why the DMN Gets Hyperactive in Depression In depressive disorder and chronic anxiety, the DMN becomes hyperactive and excessively rigid (hyper-connected within itself).
Pathological Rumination: An overactive DMN traps the brain in an endless loop of negative self-focused thoughts: replaying past mistakes, catastrophizing the future, and reinforcing negative beliefs ("I am broken," "Nothing will work out").
Loss of Network Switching: The DMN fails to quiet down when the person tries to engage with the outside world. This makes it difficult to concentrate on tasks because internal self-criticism continuously overrides sensory experience.
Rigid "Mental Grooves": Over time, high functional connectivity in the DMN strengthens these self-deprecating neural pathways, making negative thinking patterns automatic and hard to break.
The Psychedelic Experience
As you become more present and happy, your thoughts begin to change.
Psychedelics in Bars
Psilocybin can be added to ethanol to increase appreciation of music, art and conversation. Recreational psychdelic use improves wellbeing.
Psychedelics lower mental hindrances like distraction.
Mushrooms may have helped steve jobs become one of the greatest entrepeneur of all time. Mushrooms improve focus which steve jobs said is the most important thing in doing great work. Mushrooms improve this. Mushrooms are also common in cultures like burning man. The founders of google hired Eric Schmidt because he went to burning man. https://burningman.org/about-us/10-principles/
First Rate Madness
This book says that some mental conditions are a hindrance in one context might be a virtue in another. https://www.amazon.com/First-Rate-Madness-Uncovering-between-Leadership/dp/1455125237
Mushroom Legalization
Mushrooms help with consciousness research and help find our place in the universe
Consciousness is an important part of life.
Mushrooms help with managing emotions and this improves mindsets
Kerpow
Psychedelics increaes grattitude and appreciation which makes more happiness
Most things people do in life are to gain happiness. Transitive Propery means we go from A->B->C. But psycheelics and meditaiton make it go from A->C which means we directly get happiness. That means we get more choice and executive function which are known to be a good thing.
Mushrooms improve creativity, productivty
Mushrooms also alleviate stress which make work more fun. https://www.nature.com/articles/s41398-021-01335-5?utm_source=chatgpt.com https://pubmed.ncbi.nlm.nih.gov/41187880/?utm_source=chatgpt.com
Mushrooms help with concentration, relaxation and avoiding distraction.
Lowering Legal Latency
Psychedelics can help create governance structures that are multi-directional. This means instead of a single leader, everyone leads each other.
psilocybin quiets activity in default mode network and then that quiets involuntary thought and self-absorption.
Psychedelics improve family bonding.
Integration Therapy
by HappyBear / Adnan Abdul Wahab 🧸
Further Research
Neuralink
Feedback Loops
"In all of human experience, there is a basic duality that defines our interaction with the world. That duality is the opposition between the conscious and the unconscious, foreground and background, substructure and superstructure. All of experience is predicated upon this fundamental, yet almost invisible distinction. In any experience of the external world, your unconscious filters out what is unimportant, otherwise it would be impossible for your brain to extract patterns from such enormous swathes of information (all of the visual, aural, and tactile stimulation that your nerves are recording at every moment of your life). If you are exposed to any stimulus long enough, it congeals into a background entity, swept behind the curtain of your consciousness, and ceases to be an object of direct perception. This is obvious with things like putting on pants or wearing sunglasses—at first, it is an object of experience, but as it the experience is repeated (the feeling of having your leg press against denim or seeing an object shaded darker than it usually is), your brain filters it out and you no longer notice it. In a way, this is what happens in games like poker as well." https://haseebq.com/beauty-in-poker/
paul graham helped invent openAI by writing a blog and then that helped recruit the first batch of ycombinator students. IF everyone writes a blog then there might be more good ideas!
Refillable Nitrous Stations
Nitrous Oxide is known to help with studying and work. It can help make difficult problems easier to solve as a reward to support feedback loops.
The moment
“The person who find the moment by accident, and that’s typically how it happens, he experiences the glory of the moment – there are no thoughts, no emotions…it’s this feeling of great peace” The Moment
— With Love and Thank you - HappyBear / Adnan Abdul Wahab 🧸🌈
Thanks to Mark Chatkhan and Will Schneiderfor editing this document.
Presence and Morality
presence → less automatic reaction → more emotional regulation → more empathy/acceptance → better communication → healthier relationships
https://pubmed.ncbi.nlm.nih.gov/31971095/ https://pubmed.ncbi.nlm.nih.gov/29309198/ https://pubmed.ncbi.nlm.nih.gov/17935531/?utm_source=chatgpt.com https://pmc.ncbi.nlm.nih.gov/articles/PMC6153889/?utm_source=chatgpt.com https://pmc.ncbi.nlm.nih.gov/articles/PMC9941505/?utm_source=chatgpt.com
Neuroplasticity: making the brain easier to change
Under the REBUS hypothesis: “I'm worthless.” ↓ psychedelic state “Maybe I'm not as certain about that as I thought.” ↓ previously discounted evidence gets more weight “There are actually people who care about me.”
psychedelics may loosen powerful priors
Psychedelics help with
- Depression
- Anxiety
- addiction
- compulsive behavior
- well being
- Cognitive flexibility / getting unstuck
- Social anxiety / connection
happiness & well-being, flexibility & rumination, emotional processing, connection, habits, and meaning
rigidity → flexibility rumination → alternative interpretations avoidance → emotional engagement fear → reappraisal disconnection → connectedness hopelessness → meaning/possibility death anxiety → acceptance compulsive behavior → greater behavioral choice low well-being → improved well-being
Human brain changes after first psilocybin use
Low dose ████ 20% Psilocybin ██████████████ 72% Psilocybin + intensive psychological/spiritual practice ██████████████████ 92%
At twelve months the participants also reported an average 32.5% positive mood-change score on the Persisting Effects Questionnaire. No participant reported that LSD had decreased their well-being or life satisfaction Link to study
10/14 participants at one year considered it among the 10 most meaningful experiences of their lives. link to study
(Link to Study)[https://pubmed.ncbi.nlm.nih.gov/42616497/]
At one month: 92.2% said they had benefited from the experience. 58.6% ranked it among the 10 most meaningful experiences of their life.
| Study | Design | Measure | Numerical result | Evidence strength | |---|---|---|---|---| | Lyons et al., 2026 | 28 healthy, psychedelic-naive adults; 25 mg vs 1 mg psilocybin within-subject | WEMWBS well-being | +5.83 points at 2 weeks; +4.70 at 1 month vs control | ⭐⭐⭐⭐ | | Griffiths et al., 2018 | 75 healthy adults, randomized, double-blind; low vs high-dose psilocybin | Well-being/life satisfaction | Mean +1.08 vs +2.20/+2.60 on −3 to +3 scale at 6 months; 20% vs 72%/92% reported moderate/very large increases | ⭐⭐⭐⭐ | | Carhart-Harris et al., 2021 | 59 people with depression, randomized psilocybin vs escitalopram | WEMWBS + Flourishing | Well-being +15.4 vs +7.3 points; flourishing +14.4 vs +9.0 at 6 weeks | ⭐⭐⭐⭐ | | Schmid & Liechti, 2017 | 16 healthy adults, 200 μg LSD; long-term follow-up | Life satisfaction/well-being | +1.0 at 1 month → +1.4 at 12 months on −3 to +3 scale | ⭐⭐⭐ | | Korthuis et al., 2026 | 346 people receiving legal Oregon psilocybin services | SWEMWBS + life satisfaction | +3.21 well-being points at 3 months; life satisfaction RR 1.31 | ⭐⭐⭐ |
References
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10545967/?utm_source=chatgpt.com - At 2–4 weeks and again at 2–3 months, 84–89% reported desirable improvements in well-being or life satisfaction.
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https://pmc.ncbi.nlm.nih.gov/articles/PMC8277190/?utm_source=chatgpt.com - Improvements in clusters the researchers called “Being Well” and “Staying Well” persisted in the available follow-up data for as long as two year
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https://pubmed.ncbi.nlm.nih.gov/27909165/
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https://www.who.int/publications/i/item/9789240080737?utm_source=chatgpt.com
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Consensus rather than majority conflict- https://doi.org/10.1126%2Fscience.adq2852?utm_source=chatgpt.com
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Better psychiatric diagnostics - https://www.nimh.nih.gov/about/organization/dtr/adult-psychopathology-and-psychosocial-interventions-research-branch/translational-digital-and-computational-psychiatry-program?utm_source=chatgpt.com
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https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=cba7628c-30b2-5d26-e053-2a95a90a3e57&utm_source=chatgpt.com
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Digital Biomarkers & Computational Psychiatry:
Insel, T. R. (2017). Digital phenotyping: technology for a new science of psychiatry. World Psychiatry, 16(2), 121–122. 100. https://www.paulgraham.com/say.html?utm_source=chatgpt.com
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Targeting Dopamine/Serotonin Novel Pathways:Kaul, I., et al. (2024). Efficacy and safety of Xanomeline-Trospium (KarXT) in schizophrenia. The New England Journal of Medicine / FDA approval literature for Muscarinic agonists (Cobenfy).Why add it: Validates your call for "next-generation pharmaceuticals" moving beyond traditional $D_2$ receptor antagonism.
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https://bost.ocks.org/mike/algorithms/
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Citation: Valsangiacomo, C. (2021). Clarifying Liquid Democracy. American Political Science Review.
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Citation: Posner, E. A., & Weyl, E. G. (2018). Radical Markets: Uprooting Capitalism and Democracy for a Just Society. Princeton University Press.
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https://maps.org/
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how to change your mind
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already free - bruce tift
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https://pmc.ncbi.nlm.nih.gov/articles/PMC3909994/pdf/fnhum-08-00020.pdf
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https://dmvaldman.github.io/schizorationality/ misdiagnosed with schizophrenia
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https://pubmed.ncbi.nlm.nih.gov/34108247/
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https://chatgpt.com/c/6ac6aa5c-6f04-83e8-8c03-0c51135e2347#:~:text=Compassion%20Training%20Alters%20Altruism%20and%20Neural%20Responses%20to%20Suffering
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https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2798510?utm_source=chatgpt.com
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https://pubmed.ncbi.nlm.nih.gov/37264950/?utm_source=chatgpt.com
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https://chatgpt.com/c/6ac6aa5c-6f04-83e8-8c03-0c51135e2347#:~:text=Scaling%2Dup%20treatment%20of%20depression%20and%20anxiety%3A%20a%20global%20return%20on%20investment%20analysis
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Reducing conflict and containment rates on acute psychiatric wards: The Safewards cluster randomised controlled trial https://pubmed.ncbi.nlm.nih.gov/26166187/?utm_source=chatgpt.com
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JAMA Network Weng et al. (2013). Compassion Training Alters Altruism and Neural Responses to Suffering. Psychological Science, 24(7), 1171–1180. DOI: 10.1177/0956797612469537.
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https://pmc.ncbi.nlm.nih.gov/articles/6082376/?utm_source=chatgpt.com
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https://pmc.ncbi.nlm.nih.gov/articles/PMC9526145/
TODO - add voting to game - vote with people in the game - talk to them to update each others thinking
- https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1923284/full#sec17
